Why You’ll Love This Recipe

This pizza casserole is the definition of comfort food. The biscuit dough is soft and fluffy, while the pepperoni, cheese, and pizza sauce make it taste just like your favorite pizza. It’s quick, easy, and full of cheesy goodness. This dish is perfect for a weeknight meal, a potluck, or even a fun family dinner. Plus, you can customize it with your favorite pizza toppings to make it your own.

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

2 (1-lb) cans buttermilk biscuits
1 (7-oz) package pepperoni
3-4 cups mozzarella cheese, divided
2 (16-oz) jars pizza sauce, divided
1 tablespoon Italian seasoning, divided
3 tablespoons Parmesan cheese, grated

Directions

Preheat the oven: Preheat your oven to 350°F (175°C). Grease a deep 9×13 inch casserole dish with nonstick spray.
Prepare the biscuits: Open the first can of biscuits and cut them into sixths (cut each biscuit in half, then cut each half into 3). Layer them on the bottom of the casserole dish.
Add the pepperoni: Cut half of the pepperoni slices into quarters using scissors and spread them over the top of the biscuits.
Add mozzarella cheese: Sprinkle 1 and 1/2 cups of mozzarella cheese over the top of the pepperoni.
Add pizza sauce: Spread 1 jar of pizza sauce over the top, then sprinkle with half a tablespoon of Italian seasoning.
Add another layer: Open the second can of biscuits and cut them in the same way. Layer them over the first biscuit layer. Add the remaining half of the pepperoni (cut into quarters) and drizzle with half of the remaining pizza sauce. Sprinkle with the remaining Italian seasoning.
Add cheese: Top with 1 to 2 cups of mozzarella cheese, depending on how cheesy you want it.
Add Parmesan cheese: Grate 3-4 tablespoons of Parmesan cheese over the top for extra flavor.
Cover and bake: Spray a sheet of foil with nonstick spray and cover the casserole. Place the casserole dish on a large baking sheet (in case it bubbles over). Bake at 350°F for about 60 minutes.
Uncover and brown: After 60 minutes, uncover the casserole and continue baking for 10-15 more minutes, until the top is golden brown and bubbly. Use a toothpick or fork to test a biscuit in the middle to ensure it’s cooked through. If not, cover and return to the oven until fully cooked.
Serve: Serve the casserole hot with the leftover pizza sauce, warmed in the microwave, for dipping!

Servings and Timing

Servings: This recipe makes 12 servings.
Prep time: 10 minutes
Cook time: 1 hour
Total time: 1 hour 10 minutes

Variations

Vegetarian Pizza Casserole: Omit the pepperoni and add your favorite pizza veggies, such as mushrooms, bell peppers, olives, or spinach.
Spicy Pizza Casserole: Add some sliced jalapeños or crushed red pepper flakes for a spicy kick.
Extra Cheesy: Add more mozzarella or experiment with different types of cheese, like cheddar or provolone, for more flavor.

Storage/Reheating

Storage: Store leftover pizza casserole in an airtight container in the refrigerator for up to 3-4 days.
Reheating: Reheat the casserole in the microwave or oven at 350°F for about 10-15 minutes until heated through.

FAQs

1. Can I use a different type of meat in this casserole?

Yes, you can substitute the pepperoni with cooked ground beef, sausage, or even chicken for a different twist.

2. Can I use frozen biscuits for this recipe?

Yes, frozen biscuits will work as well. Just make sure to thaw them before cutting and layering in the casserole.

3. Can I make this casserole ahead of time?

Yes, you can prepare the casserole the night before and refrigerate it. When ready to bake, just add 10-15 minutes to the cooking time.

4. Can I use homemade pizza sauce?

Definitely! If you prefer homemade pizza sauce, feel free to use it in place of store-bought sauce.

5. Can I make this casserole without cheese?

If you’re looking for a cheese-free version, you can skip the cheese or substitute it with a dairy-free option.

6. How can I make this casserole spicier?

To add more heat, sprinkle in some crushed red pepper flakes, or use a spicy sausage or hot pepperoni instead of regular pepperoni.

7. Can I make this gluten-free?

If you need a gluten-free version, look for gluten-free biscuits and ensure your pizza sauce is gluten-free.

8. Can I freeze this casserole?

Yes, this casserole can be frozen. Prepare it as directed, but do not bake. Cover tightly with foil and freeze for up to 3 months. To cook, bake from frozen at 350°F for 60-70 minutes, then uncover and bake for an additional 10-15 minutes.

9. What can I serve with pizza casserole?

This casserole is hearty on its own, but you can serve it with a side salad, garlic bread, or even some sautéed vegetables.

10. How do I know when the casserole is done?

The casserole is done when the top is golden brown and bubbly. Insert a toothpick into the center to make sure the biscuits are cooked through.

Conclusion

This Easy Pizza Casserole is the ultimate comfort food, combining all the flavors of pizza in one easy-to-make casserole. With layers of fluffy biscuit dough, savory pepperoni, mozzarella, and pizza sauce, it’s a family favorite that’s sure to be a hit. Whether you’re looking for a quick dinner or something to serve at a potluck, this pizza casserole will definitely satisfy everyone’s cravings!

Easy Pizza Casserole

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Easy Pizza Casserole is a comforting, cheesy dish made with layers of biscuit dough, pepperoni, mozzarella, and pizza sauce. It’s quick to make, perfect for busy nights or a fun family dinner.

Author: Amy
Prep Time: 10 minutes
Cook Time: 1 hour
Total Time: 1 hour 10 minutes
Yield: 12 servings
Category: Main Dish
Method: Baking
Cuisine: American

Ingredients

2 (1-lb) cans buttermilk biscuits

1 (7-oz) package pepperoni

3–4 cups mozzarella cheese, divided

2 (16-oz) jars pizza sauce, divided

1 tablespoon Italian seasoning, divided

3 tablespoons Parmesan cheese, grated

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Instructions

Preheat the oven: Preheat your oven to 350°F (175°C). Grease a deep 9×13 inch casserole dish with nonstick spray.
Prepare the biscuits: Open the first can of biscuits and cut them into sixths (cut each biscuit in half, then cut each half into 3). Layer them on the bottom of the casserole dish.
Add the pepperoni: Cut half of the pepperoni slices into quarters and spread them over the top of the biscuits.
Add mozzarella cheese: Sprinkle 1 and 1/2 cups of mozzarella cheese over the top of the pepperoni.
Add pizza sauce: Spread 1 jar of pizza sauce over the top, then sprinkle with half a tablespoon of Italian seasoning.
Add another layer: Open the second can of biscuits, cut them the same way, and layer them over the first biscuit layer. Add the remaining pepperoni (cut into quarters) and drizzle with the remaining pizza sauce. Sprinkle with the remaining Italian seasoning.
Add cheese: Top with 1 to 2 cups of mozzarella cheese, depending on how cheesy you want it.
Add Parmesan cheese: Grate 3-4 tablespoons of Parmesan cheese over the top.
Cover and bake: Spray a sheet of foil with nonstick spray and cover the casserole. Bake at 350°F for about 60 minutes.
Uncover and brown: After 60 minutes, uncover the casserole and bake for an additional 10-15 minutes, until the top is golden brown and bubbly. Test with a toothpick to ensure the biscuits are cooked through.
Serve: Serve the casserole hot, with extra pizza sauce on the side for dipping.